- Life sciences
DNA Sequencers
The challenge
Modern DNA sequencers face significant optical and system-level challenges in delivering higher throughput and accuracy. Homogeneous illumination of the cell flow is essential to ensure consistent signal quality and reliable base calling across millions of reads. At the same time, precise and uniform mixing of multiple laser wavelengths is required to excite different fluorescent labels with equal efficiency. As sequencing demand grows, systems must support faster flow rates without compromising optical stability, signal uniformity, or data integrity—enabling shorter run times and higher productivity in life science laboratories.
Our solution
In DNA sequencing systems, placing speckle reducers after mixed laser sources is critical for achieving uniform illumination. By effectively homogenizing the combined laser beams, speckle reducers minimize intensity fluctuations that can degrade image quality. This results in a significantly improved signal-to-noise ratio at the sensor, enabling more reliable fluorescence detection and base calling. With cleaner, more uniform illumination, cell flow speeds can be increased without compromising sequencing accuracy, supporting higher throughput and faster run times while maintaining the stringent quality requirements of life science applications.
Why Optotune for DNA sequencers
Related products
Related topics
Learn how Optotune’s LSR-4C reduces laser speckle to improve image and measurement quality.
Reduce speckle, enhance performance – LSR-4C explained.
Related applications
- Support
Get in touch with us
Not sure if our products will fit your setup? Our team is here to answer your questions. Contact us and discover how we can support you.